Noscapine (hydrochloride)

(3S)-6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone, monohydrochloride
\n Noscapine is an opioid alkaloid with antitussive and antimitotic properties.{28232} It binds to tubulin and arrests mammalian cells in mitosis at a concentration of 20 µM.{28233} Noscapine induces apoptosis (IC50 = 25 and 10 µM in HeLa cells and thymocytes, respectively) and demonstrates antitumor activity both in vitro (IC50 = 42.3 and 39.1 µM in MCF-7 and Renal 1983 cell lines, respectively) and in mice.{28233}