2-[(diphenylmethyl)sulfinyl]-acetamide
\n Modafinil (Item No. 15417) is an analytical reference standard that is classified as a nootropic. It is a wake-promoting agent that binds competitively and selectively to the dopamine transporter, modulating catecholaminergic signaling by inhibiting its activity (IC50 = 3 μM; Ki = 2 μM).{25142} With much weaker potency, modafinil can bind the norepinephrine transporter (IC50 50 > 500 μM).{25145} Aside from its utility in sleeping disorders, modafinil has also been explored for treating the symptoms of fatigue that are often associated with multiple sclerosis (and other diseases) and as an intervention for cognitive impairments associated with drug addiction.{25144,25146,25143} This product is intended for forensic and research applications.
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