(1-(4-hydroxypentyl)-1H-indol-3-yl)(naphthalen-1-yl)-methanone
\nJWH 018 is a mildly selective agonist of the peripheral cannabinoid (CB2) receptor, derived from the aminoalkylindole WIN 55,212-2. The Ki values for binding central cannabinoid (CB1) and CB2 receptors are 9.0 and 2.94 nM, respectively, for a CB1:CB2 ratio of 3.06.{16797} JWH 018 is one of several synthetic CBs which have been included in smoking mixtures.{18291,19507} (±)-JWH 018 N-(4-hydroxypentyl) metabolite is a urinary metabolite of JWH 018, characterized by monohydroxylation of the N-alkyl chain.{19353} Its biological actions are unknown.
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