JWH 007-d9

(2-methyl-1-pentyl-1H-indol-3-yl)-1-naphthalenyl-2,2,3,3,4,4,5,5,5-d9-methanone
\n JWH 007-d9 contains nine deuterium atoms at the 2, 2’, 3, 3’, 4, 4’, 5, 5, and 5 positions. It is intended for use as an internal standard for the quantification of JWH 007 by GC- or LC-mass spectrometry (MS). JWH 007 is a potent cannabinoid (CB) receptor agonist that avidly binds to both CB1 and CB2 (Ki = 9.5 and 2.9 nM, respectively).{18231,18232} This compares favorably with the binding of Δ9-THC, which binds CB1 and CB2 with Ki values of 41 and 36 nM, respectively.{18232} Similarly, JWH 007 performs comparably to Δ9-THC in murine studies on spontaneous activity, antinociception, hypothermia, and catalepsy.{18231}