Join Amsphere A+ Beta Program
Introduction to JSR Corporation
JSR Corporation is a global leader in innovative materials, dedicated to advancing life sciences. Our expertise and commitment to excellence drive us to develop groundbreaking solutions for the biopharmaceutical industry.
Overview of Amsphere™ Protein A Resins
Our Amsphere™ line of Protein A resins is designed for superior affinity purification, ensuring high yield and purity in antibody production. These resins are essential in the downstream process of antibody drug production.
Features of Amsphere™ A3
Amsphere™ A3 is the next generation protein A affinity resin with outstanding performance features:
- High Dynamic Binding Capacity (DBC): Maximizes antibody capture, reducing process time and increasing yield.
- Superior Caustic Stability: Maintains performance even under rigorous cleaning conditions, capable of withstanding up to 300 cycles with 0.1 M NaOH.
- Impurity Clearance: Achieves industry-standard impurity clearance, ensuring low levels of HCP, DNA, and aggregates.
Amsphere™ A3 is already in use for GMP manufacturing in clinical and commercial stages, demonstrating its robustness and reliability in various applications, including Fc-fusion molecules and antibody fragments. Download the brochure here.
Introducing the New Amsphere™ A+
Amsphere™ A+ is the latest addition to our Amsphere™ product line, offering several enhancements:
- Improved DBC and Pressure Properties: Features a newly designed Protein A ligand and base matrix, providing better performance.
- Alkali Stability: Demonstrates significantly improved stability with a novel Protein A ligand, making it suitable for extended use.
- Affinity for Non-Classical mAbs: Shows strong affinity for non-classical mAbs such as Fc fusion and bispecific antibodies.
Amsphere™ A+ maintains stable DBC and recovery yield performance while minimizing HCP and Protein A leach throughout its lifecycle. Download the brochure here.
Invitation to the Beta Program
We are excited to invite you to participate in our exclusive beta program for Amsphere™ A+. This program offers you the opportunity to:
- Evaluate New Technology: Be among the first to test and benefit from our latest advancements in Protein A chromatography resins.
- Provide Feedback: Share your insights and experiences to help us further enhance our products.
- Optimize Your Processes: Gain access to cutting-edge resins that can improve your antibody purification processes.
JSR Life Sciences' products are distributed by Fujifilm Wako in Japan and Novachem in Australia. We specifically invite Novachem customers and Australian researchers and biopharmaceutical producers to trial Amsphere™ A+. Additionally, the existing Amsphere™ A3 product is available for purchase for those interested in established solutions.
A complete redesign, this resin is capable of achieving exceptional capacity and flow rates, surpassing its predecessor, the Amsphere A3.
- With its impressive 1M NaOH tolerance, A+ offers unparalleled durability and longevity, even in the most demanding production environments where bioburden control is essential.
- Product launch: GMP-use resin (incl. RSF) and validated product is targeted for Sep 2024.
- This is a collaborative program seeking select beta testers that can test on multiple molecules and to obtain feedback in its usability and quality of purification.
Proposal for experimental scope and feed-back structure:
- Ability to test on ≥ 2 molecules
- At least two flow rates of interest (for DBC) that are important for your PD/manufacturing needs
- Comparative data and feedback:
- DBC (2x flow rates)
- Quality of purification (HCP, ProteinA leachate, DNA, etc.)
- Chromatogram (elution profile, CV)
- Usability of the product and any concerns
Join us in shaping the future of biopharmaceutical production.