JWH 073 N-butanoic acid metabolite

4-(3-(1-naphthoyl)-1H-indol-1-yl)-butanoic acid
\nJWH 073 is a mildly selective agonist of the central cannabinoid (CB1) receptor derived from the aminoalkylindole WIN 55,212-2. The Ki values for binding CB1 and the peripheral cannabinoid (CB2) receptor are 8.9 and 38 nM, respectively for a CB1:CB2 ratio of 0.23.{16797} JWH 073 is one of several synthetic CBs which have been included in smoking mixtures. JWH 073 N-butanoic acid metabolite is expected to be a urinary metabolite of JWH 073, characterized by carboxylation of the N-alkyl chain, based on the metabolism of the closely-related JWH 015 and JWH 018.{18292,18291} In urine samples, this metabolite of JWH 018 is almost completely glucuronidated.{18291}