CIL announces new 13C Polycyclic Aromatic Compounds
The advantages of 13C-labeled over deuterated internal standards to improve the accuracy and lower detection limits in the analysis of polyaromatic compounds (PACs) have been documented many times over the years. The 13C standards have a distinct advantage because they are not susceptible to deuterium back-exchange during extraction and cleanup, a phenomenon that can adversely affect recoveries when using deuterated standards.
Cambridge Isotope Laboratories, Inc. (CIL) and Cerilliant have produced 13C-labeled PACs since the mid-1990s. The core group of 16, based on polycyclic aromatic hydrocarbons (PAHs) targeted by the US EPA and the California Air Resources Board (CARB), were synthesized and formulated at that time. Since then, other groups have evaluated PACs (mostly PAHs) for toxicity and carcinogenicity; comparisons of some of the lists are summarized inside.
These PAHs may become of greater interest to regulators as more is learnedabout their toxicity, carcinogenicity, bioaccumulative persistenceand other factors that might make them be considered more harmful than previously thought.
Based on these lists and customer input, CIL has undertaken further syntheses of the following 13C PACs, with several
more in development.